You still have meaningful weight management options through Oana — even without access to GLP-1 medications. The Oana catalog includes several non-GLP-1 treatments that address PCOS-related weight through different underlying mechanisms, and they ship to all 50 states.
Your options:
Metformin ER. A long-established prescription medication that improves how your body responds to insulin — addressing the insulin resistance that drives a significant portion of PCOS-related weight gain. Particularly relevant if your weight pattern includes carb cravings, energy crashes, and the sense that diet and exercise haven't moved the scale the way they should. Taken as a once-daily tablet. Ships nationwide. See "What is Metformin ER?" for the full picture.
Bupropion. An oral prescription medication that works on appetite regulation, food cravings, and energy — different mechanisms than GLP-1 medications, but with documented weight management effects. Bupropion is one of the two active ingredients in Contrave, an FDA-approved weight management medication. Particularly relevant if your weight pattern includes strong cravings, low energy, or a mood dimension alongside the physical symptoms. Ships nationwide. See "What is Bupropion?" for the full picture.
Spironolactone-based protocols. For women whose PCOS includes weight alongside acne, unwanted hair, or hair loss, Spironolactone addresses the elevated androgens that contribute to PCOS as a whole. While not a primary weight loss medication, treating the underlying hormonal picture can have downstream effects on weight, cycle, and energy. Often prescribed alongside Metformin (as MetSpiro) for women with both insulin resistance and androgen-driven symptoms.
Topical Metformin. A complement rather than a primary weight treatment — it's useful for women whose PCOS includes skin issues (acne, melasma) where the localized version of Metformin works alongside an oral weight management protocol.
How to start:
Submit your Oana medical intake. In the intake, you'll share your symptoms, what you've already tried, and your specific weight goals. Your Oana clinician will review your case and recommend the protocol most likely to work for you — including, if helpful, a combination of treatments.
The state restrictions on GLP-1 medications are a real limitation — they affect what's available in your state. But they don't mean you're without options. Metformin and Bupropion in particular have been used for PCOS-related weight management for decades, and for many women with insulin resistance or craving-driven weight patterns.
If your circumstances change — for example, if you move to a state where GLP-1s are available, or if regulations in your state shift — your Oana clinician can adjust your protocol at that point. For now, the goal is to start with what's available and most likely to help.