Bupropion is generally well-tolerated, but side effects in the first few weeks are common as your body adjusts. Most are mild and improve over time.
Common side effects:
- Loss of appetite one of the most common effects, and part of what makes Bupropion useful for weight management. Worth being aware of, particularly in the early weeks.
- Headaches most common in the first 1 to 2 weeks.
- Insomnia or sleep changes Bupropion can be activating, particularly when taken later in the day. Taking it in the morning helps reduce this for most women.
- Nausea, particularly in the first weeks.
- Dry mouth.
- Constipation.
- Dizziness.
Less common side effects:
- Increased anxiety or restlessness, particularly in the first weeks.
- Tremor or shaky hands.
- Sweating.
- Joint or muscle pain.
- Changes in mood or behavior including unusual irritability or emotional changes.
Serious side effects requiring immediate attention:
- Seizures Bupropion lowers the seizure threshold, particularly at higher doses or in people with risk factors. Seizures while on Bupropion are uncommon at typical prescribed doses but require immediate emergency attention.
- Severe allergic reaction rash, swelling of the face, difficulty breathing, severe itching.
- Mood changes including suicidal thoughts particularly in the first weeks of starting or after dose changes. Seek immediate care or contact a crisis resource.
- Confusion or significant disorientation.
- Severe blood pressure increase symptoms include severe headache, vision changes, or chest pain.
What to do:
- Most common side effects improve within 2 to 4 weeks as your body adjusts.
- Take it in the morning to reduce sleep effects.
- Stay hydrated to help with dry mouth and constipation.
- Message your clinician if side effects are bothersome or persistent.
- Don't stop suddenly Bupropion is often tapered when discontinuing.
- Seek immediate care for seizures, severe allergic reactions, significant mood changes including suicidal thoughts, or severe blood pressure symptoms.
If you're experiencing suicidal thoughts or thoughts of self-harm, contact the 988 Suicide & Crisis Lifeline (call or text 988), go to your nearest emergency room, or contact your Oana clinician immediately.