An affordable bundle that combines two PCOS powerhouses — addressing both insulin resistance and androgen excess in one plan.
The Metformin & Spironolactone Pack pairs Metformin ER 500mg with Spironolactone 50mg to attack PCOS from both angles. Metformin improves insulin sensitivity and lowers androgens at their metabolic root, while Spironolactone directly blocks androgen activity at the receptor level. Together, they offer the most comprehensive approach to managing PCOS symptoms.
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PCOS is driven by two interconnected problems: insulin resistance and excess androgens. Most treatments target only one of these pathways, leaving the other unchecked. That's why many women find that a single medication helps some symptoms but not others.
Metformin ER tackles the metabolic side — improving how your body uses insulin, which reduces the hormonal signal that tells your ovaries to overproduce androgens. Spironolactone works on the hormonal side — directly blocking androgen receptors in your skin and hair follicles. Together, they attack PCOS from both the source and the symptoms.
Think of it this way: Metformin turns down the volume on androgen production, while Spironolactone blocks the speakers. The combination is more effective than either medication alone because it addresses the full spectrum of PCOS.
Get Started — $32/mo →Two distinct mechanisms working in tandem to address the full complexity of PCOS.
Research consistently shows that combination therapy outperforms monotherapy for PCOS management.
Clinical studies comparing Metformin plus Spironolactone against either drug alone have found that the combination approach leads to greater improvements in androgen levels, menstrual regularity, and skin-related symptoms. The drugs complement each other — Metformin addresses the metabolic root cause while Spironolactone provides faster symptomatic relief at the tissue level.
The combination approach covers the full range of PCOS symptoms that single medications often miss.
Metformin ER improves how your cells respond to insulin, reducing the metabolic driver behind most PCOS symptoms.
Metformin ERSpironolactone blocks androgens at the skin level, reducing oil production and clearing persistent breakouts.
SpironolactoneExcess facial and body hair growth slows as Spironolactone blocks androgen receptors in hair follicles.
SpironolactoneMetformin helps restore ovulation by correcting the insulin-androgen imbalance that disrupts your cycle.
Metformin ERBoth medications contribute — Metformin reduces androgen production, Spironolactone blocks remaining androgens from damaging follicles.
BothMetformin normalizes insulin signaling, reducing hunger and making it easier for your body to use stored fat for energy.
Metformin ERTake your Metformin ER 500mg tablet with your evening meal, ideally with fiber-rich food. The extended-release formulation works best when taken with a full meal, and the slow absorption minimizes stomach discomfort.
Take your Spironolactone 50mg tablet once daily. It can be taken at the same time as Metformin or at a different time — consistency matters more than timing. Many patients take it in the morning with breakfast.
Spironolactone is a mild diuretic, so drink plenty of water throughout the day. This also helps Metformin work more effectively and reduces the chance of GI side effects.
Take both medications at the same time each day. Both Metformin and Spironolactone work best with consistent daily use — skipping doses reduces their effectiveness and can cause symptoms to return.
Combination therapy takes time to reach full effect. Here's what most patients experience.
Your body adapts to both medications. Mild GI symptoms from Metformin typically resolve within the first 2-4 weeks. You may notice slightly increased urination from Spironolactone. Some patients see early improvements in oil production and energy levels.
This is when most patients start seeing real results. Acne begins clearing, periods may become more regular, cravings and energy levels stabilize. Hair growth may start to slow, though this takes longer to become fully visible.
By six months, the full benefits of combination therapy are typically apparent. Menstrual cycles are more predictable, skin is clearer, hirsutism is visibly reduced, and metabolic markers show improvement. Many patients feel like a different person.
Knowing which side effects come from which medication helps you and your provider manage them effectively.
These typically resolve within the first 2-4 weeks. The ER formulation significantly reduces GI side effects compared to standard metformin. Taking it with food helps.
Staying well-hydrated helps with most spironolactone side effects. Dizziness usually resolves as your body adjusts.
Important: Spironolactone must not be taken during pregnancy. Effective contraception is required while using this medication.
Yes, you can take both medications at the same time if that's more convenient. Many patients take Spironolactone in the morning and Metformin ER with dinner, but taking them together with an evening meal is also fine. Your provider will recommend a schedule based on your preferences.
We bundle both medications into a single shipment with one provider consultation, which reduces costs for fulfillment, packaging, and clinical review. Those savings get passed directly to you. It's the same FDA-approved medications at a lower combined price.
Your provider may recommend periodic bloodwork to monitor kidney function (for Metformin), potassium levels (for Spironolactone), and overall metabolic markers. This is standard practice for combination therapy and helps ensure both medications are working safely.
You can absolutely get either medication individually. We offer standalone Metformin ER ($22/month) and Spironolactone ($22/month) separately. However, the pack offers the best value and the most comprehensive approach to PCOS management.
Spironolactone is not safe during pregnancy and must be discontinued before trying to conceive. If you're planning pregnancy, your provider will work with you on an alternative plan — often continuing Metformin alone, which is generally considered safe in pregnancy.
It depends on your individual situation and goals. Many patients take both medications for 6-12 months to get symptoms under control, then work with their provider to adjust the plan. Some patients benefit from longer-term use alongside lifestyle modifications.
Complete a 5-minute online consultation. A licensed provider will review your information and determine if the Metformin & Spironolactone Pack is right for you.
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